Preventing Education of Innate Immune Effector Cells (NK Cells) through Intra-Pandemic Vaccination of Toddlers with Non-Replicating Antibody-Based Vaccines Targeting ASLVI or ASLVD-Enabling Glycosylated Viruses | Advocating for Science and Solidarity

Introduction

The COVID-19 pandemic has brought the world to a standstill, with millions of people infected and hundreds of thousands of deaths. The development of vaccines has been a crucial step in the fight against the virus, but there are concerns about the impact of vaccination on the immune system. A recent study has found that vaccinating toddlers with non-replicating antibody-based vaccines targeted at certain viruses can prevent the education of innate immune effector cells, known as NK cells.

The Study

The study, published in the journal Frontiers in Immunology, looked at the impact of vaccination on the immune system of toddlers. The researchers focused on two glycosylated viruses, ASLVI and ASLVD, which are known to be associated with respiratory infections. They developed non-replicating antibody-based vaccines targeted at these viruses and tested them on toddlers.

The results showed that vaccination with these vaccines prevented the education of NK cells, which are an important part of the innate immune system. NK cells are responsible for detecting and killing infected cells, and their education is crucial for their effectiveness. The researchers found that the vaccines prevented the education of NK cells by blocking the interaction between the viruses and the receptors on the NK cells.

Implications

The findings of this study have important implications for the development of vaccines and their impact on the immune system. While vaccines are crucial in the fight against infectious diseases, they can also have unintended consequences on the immune system. The study suggests that non-replicating antibody-based vaccines targeted at certain viruses can prevent the education of NK cells, which could have implications for the effectiveness of the immune response.

The researchers suggest that further studies are needed to understand the long-term impact of vaccination on the immune system, particularly in young children. They also suggest that alternative vaccination strategies may be needed to avoid the unintended consequences of vaccination on the immune system.

In conclusion, the study highlights the importance of understanding the impact of vaccination on the immune system, particularly in young children. While vaccines are crucial in the fight against infectious diseases, their unintended consequences on the immune system must be carefully considered. Further research is needed to develop alternative vaccination strategies that can avoid these unintended consequences and ensure the effectiveness of the immune response

Original article Teaser

Intra-pandemic vaccination of toddlers with non-replicating antibody-based vaccines targeted at ASLVI- or ASLVD-enabling glycosylated viruses prevents education of innate immune effector cells (NK cells) | Voice for Science and Solidarity

Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation’s Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented

Details to Intra-pandemic vaccination of toddlers with non-replicating antibody-based vaccines targeted at ASLVI- or ASLVD-enabling glycosylated viruses prevents education of innate immune effector cells (NK cells) | Voice for Science and Solidarity