Die Korrespondenz der Generäle: Wie das menschliche Immunsystem erobert und vereinnahmt wurde – Eine Stimme für Wissenschaft und Solidarität

g antibodies and virulence-inhibiting PNNAbs to protect against severe infection. However, the immune system is struggling to produce these antibodies at sufficient levels due to the decreased ability of antigen presenting cells (APCs) to present viral antigens. This has led to a shift in the immune response from antibody-mediated to CTL-mediated, where cytotoxic T lymphocytes (CTLs) are activated to kill virus-infected cells and lessen the severity of infection.

The decrease in antibody production and reliance on CTLs is concerning because it hampers the ability to produce new neutralizing antibodies in response to updated mRNA vaccines and maintain high levels of virulence-inhibiting PNNAbs. As a result, the immune system is unable to effectively neutralize the virus and control underlying chronic disorders. Additionally, the activation of APCs by large viral aggregates and subsequent activation of CTLs can lead to a dampening of T helper cell-dependent recall and boosting of previously primed antibody production, further complicating the immune response.

In highly vaccinated individuals, the levels of virulence-inhibiting PNNAbs will continue to drop, putting pressure on the virus to evolve and propagate variants that can overcome the remaining PNNAbs. This can lead to severe disease in the lungs and other organs. Furthermore, the sidelining of NK cells throughout the vaccination campaign means that vaccinees lack the support of these effective „first responders“ in killing virus-infected cells.

Overall, the immune system in highly vaccinated individuals is facing challenges in producing new neutralizing antibodies and maintaining high levels of protective antibodies. This can have implications for the effectiveness of vaccines and the ability to control the severity of infection

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The General’s Memos Correspondence Between the Human Generals who Captured and Co-opted the Human Immune System | Voice for Science and Solidarity

(Complicated Version) Note to Reader: There are two versions of The General’s Memos —a “simplified” version and a “complicated” version.  The simplified version is intended for laypersons and health care professionals who desire a practical, comprehensible summary of Dr. Geert Vanden Bossche’s complex analysis of the COVID-19 situation. The complicated version is intended for scientists and health care professionals who have considerable background in immunology and desire a deeper scientific understanding of Dr. Vanden Bossche’s analysis and conclusions. To facilitate the reading of either version, see the list of acronyms and explanations below: NK cells: Natural Killer cells.  These are cells of the innate immune system.  They kill virus-infected human cells. They are excellent “first responders.” RBD: Receptor binding domain

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