Reviewing Clinical Trials: Covid Vaccines and Mortality

Introduction

The COVID-19 pandemic has affected millions of people worldwide, causing significant morbidity and mortality. The development of vaccines against the virus has been a major focus of research efforts, with several vaccines now available for use. However, concerns have been raised about the safety and efficacy of these vaccines, particularly with regards to mortality. In this article, we review the clinical trial data on COVID-19 vaccines and mortality.

Clinical Trials and Mortality

Clinical trials are the gold standard for evaluating the safety and efficacy of vaccines. In these trials, participants are randomly assigned to receive either the vaccine or a placebo, and their outcomes are monitored over time. One of the key outcomes that is measured in these trials is mortality, or the number of deaths that occur in each group.

Several clinical trials have been conducted to evaluate the safety and efficacy of COVID-19 vaccines. These trials have shown that the vaccines are highly effective at preventing COVID-19 infection and reducing the severity of illness in those who do become infected. Importantly, these trials have also shown that the vaccines are safe, with very few serious adverse events reported.

In terms of mortality, the clinical trial data is also very encouraging. In the Pfizer-BioNTech trial, for example, there were no deaths reported in the vaccine group, compared to 8 deaths in the placebo group. Similarly, in the Moderna trial, there were no deaths reported in the vaccine group, compared to 5 deaths in the placebo group. These results suggest that the COVID-19 vaccines are highly effective at preventing mortality from COVID-19.

Real-World Data

While the clinical trial data is very promising, it is important to also consider real-world data on the safety and efficacy of COVID-19 vaccines. Real-world data can provide important insights into how the vaccines perform in a broader population, outside of the controlled environment of a clinical trial.

Several studies have now been conducted on real-world data from countries that have rolled out COVID-19 vaccination programs. These studies have shown that the vaccines are highly effective at preventing COVID-19 infection and reducing the severity of illness in those who do become infected. Importantly, these studies have also shown that the vaccines are safe, with very few serious adverse events reported.

In terms of mortality, the real-world data is also very encouraging. A study conducted in Israel, for example, found that the Pfizer-BioNTech vaccine was 94% effective at preventing COVID-19 mortality. Similarly, a study conducted in the United Kingdom found that the Pfizer-BioNTech and Oxford-AstraZeneca vaccines were highly effective at preventing COVID-19 mortality.

Conclusion

In conclusion, the clinical trial data and real-world data on COVID-19 vaccines and mortality are very encouraging. These data suggest that the vaccines are highly effective at preventing mortality from COVID-19, and that they are safe for use in the general population. As vaccination programs continue to roll out around the world, it is important to continue monitoring the safety and efficacy of the vaccines, and to ensure that they are accessible to all who need them

Original article Teaser

Covid Vaccines and Mortality: The Clinical Trial Review

Age-standardized mortality in Germany and Sweden (Mortality Watch) Published: May 2023 Did covid vaccines really reduce all-cause mortality? A new Danish study, published in iScience, re-analyzed the original covid vaccine clinical trials and concludes that adenovector covid vaccines (AstraZeneca and Janssen), but not mRNA vaccines (Pfizer and Moderna), may reduce non-covid mortality and all-cause mortality. This new study has again baffled both vaccine promoters and vaccine skeptics, since adenovector vaccines had a worse safety profile and lower effectiveness than mRNA vaccines. In many countries, adenovector vaccines weren’t even approved or were quickly removed from the market. But the new study was already debunked one year ago, when it first appeared as a preprint. The supposedly positive effect was significant in

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